BioLife Solutions Granted U.S. Patent Covering New Method of Preserving Cells, Tissues or Organs
PRNewswire-FirstCall
OWEGO, N.Y.

BioLife Solutions Inc. (BULLETIN BOARD: BLFS) announced today that it was granted a U.S. patent that covers the methods and compositions for the preservation of cells, tissues or organs in the vitreous state.

BioLife President and CEO John G. Baust, Ph.D., said that the market for preserving cells and tissue is growing rapidly and is diverging into new technology areas, one of which is vitrification or freezing rapidly to avoid the presence of ice crystals.

Baust said, "Our core preservation technologies can be a critical factor in applying this new technology and solidifying our patent position in that area gives us a commercial foothold as that market develops." He continued, "We believe BioLife holds a unique and encompassing intellectual property position in the biological processing and preservation of cells, tissues and organs and that our technology significantly improves the viability of cells and organs for longer periods of time during transportation and storage."

The issuance of the patent specifically provides BioLife with the latest extension of its molecular-based cryopreservation technology platform and protects BioLife's use of cell death inhibitors (calpain inhibitors) in hypothermic preservation solutions necessary to improve cryopreservation outcome. With this patent the scope of the Company's proprietary preservation technology extends into the cell, tissue and organ vitrification arena by including the Company's molecular-based approaches to preservation to prevent apoptotic and necrotic cell death following the preservation process.

This patent, No. 6,921,633, titled, "Methods and compositions for the preservation of cells, tissues or organs in the vitreous state," brings the total number of issued patents that relate to its preservation solutions to four.

About BioLife Solutions, Inc.

BioLife Solutions has pioneered the next generation of preservation solutions designed to maintain the viability and health of cellular matter and tissues during freezing, transportation and storage. Based on the Company's proprietary bio-packaging technology and a patented understanding of the mechanism of cellular damage and death, these products enable the biotechnology and medical community to address a growing problem that exists today. The expanding practice of cell and gene therapy has created a need for products that ensure the biological viability of mammalian cell and tissue material during transportation and storage. The HypoThermosol® and CryoStor™ products that the Company is selling today are a significant step forward in meeting these needs.

This news release contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These forward-looking statements include any statements that relate to the intent, belief, plans or expectations of the Company or its management, or that are not a statement of historical fact. Any forward-looking statements in this news release are based on current expectations and beliefs and are subject to numerous risks and uncertainties that could cause actual results to differ materially. Some of the specific factors that could cause BioLife Solutions' actual results to differ materially are discussed in the Company's recent filings with the Securities and Exchange Commission. BioLife Solutions disclaims any obligation to update any forward-looking statements as a result of developments occurring after the date of this press release.

   Contact:  Allen & Caron Inc
             Jill Bertotti (investors)
             jill@allencaron.com
             Len Hall (media)
             len@allencaron.com
             949-474-4300

SOURCE: BioLife Solutions Inc.

CONTACT: Investors, Jill Bertotti, jill@allencaron.com, or media, Len
Hall, len@allencaron.com, both of Allen & Caron Inc, +1-949-474-4300, for
BioLife Solutions Inc.

We believe the promise of cell and gene therapies starts with the integrity of a single cell

Advancing the future of cell and gene therapy

The human body can heal itself. Cell and gene therapies are designed to augment the patient’s ability to fight disease but only if the living cells behind those therapies remain viable and functional throughout the production processes. At BioLife Solutions, our mission is to protect the integrity of cells and provide trusted tools, services, and expertise that can enable our customers to advance the development and delivery of cell and gene therapies. We believe the future of cell and gene therapies hinges on the integrity of every single cell and we are here to protect that promise.

We understand the technical demands of bioprocessing in this field, and our advanced biopreservation expertise, cell culture optimization products, innovative storage systems, and closed-system manufacturing solutions are designed to enhance process efficiency, maintain cellular viability, and ensure reproducibility at every stage. Whether scaling up from R&D, navigating clinical trials or optimizing cryopreservation protocols for commercial production, we provide the tools and experience to streamline your workflow and safeguard your therapies.

Work with experts who understand your biopreservation challenges

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Collaborative and comprehensive CDMO support

At BioLife Solutions, we partner with leading contract development and manufacturing organizations (CDMOs) to enhance their biopreservation and cell processing capabilities. By providing advanced tools, regulatory support, and process optimization strategies, we empower CDMOs to better serve therapy developers, ensuring quality, consistency, and scalability in cell therapy manufacturing.

Regulatory
readiness

Navigating the complex regulatory landscape of cell and gene therapy requires a proactive approach. BioLife Solutions offers experienced regulatory support to help prepare your biopreservation and cell processing methods to meet global standards. From IND and BLA submissions to compliance with GMP, FDA, and EMA guidelines, our solutions help streamline approval pathways.

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CellSeal®
CryoCase

Alleviate CGT container challenges like fracture risk, bag burping or high rates of particulates

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Data-driven
decision making

Stay ahead with our comprehensive Evidence Library, a curated collection of scientific publications, white papers, and case studies demonstrating the efficacy of BioLife Solutions’ technologies. Access peer-reviewed research, real-world application data, and expert insights to support your bioprocessing and regulatory strategies.

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Preserve, protect and expand cell performance

Mastering
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Ensure Regulatory Submission Readiness

Automate & Close
CGT Processes

Protect & Expand
Cell Performance