BioLife Solutions, Inc.
The study, titled "Cryopreservation of Adherent Cells: Strategies to Improve Cell Viability and Function after Thawing," was published in the January 2009 online issue of Tissue Engineering Part C. This reports the results of experiments conducted by research teams at the Fraunhofer IBMT in St. Ingbert/Sulzbach, Germany and IBET/ITQB-UNL in Oeiras, Portugal.
The study findings also confirm that despite improved cell recovery immediately after thawing for media/serum/DMSO cryopreserved cells beneath alginate, up to 50 percent cell death still occurred within 24 hours post-thawing. The authors agreed with other published data describing post-thaw survival overestimates, and suggest that the decrease in cell viability might be related to sequential apoptotic and necrotic processes not evident immediately subsequent to thawing. This supports very early BioLife research and discoveries of the phenomena of preservation-induced, delayed onset cell death.
Mike Rice, BioLife's chairman and CEO, noted, "The tissue engineering market is highly strategic for BioLife. Our products have great potential to resolve the current cell yield and shelf-life issues that often limit large scale commercialization and clinical distribution of new biologic-based therapies. We currently supply CryoStor and HypoThermosol® to several start-up customers and support product evaluations at other key companies in the tissue engineering market."
According to a 2009 analysis and report by Life Science Intelligence, the largely untapped global market potential for tissue engineering and regenerative medicine products will exceed $118 billion by 2013. The actual current market, which represents only a fraction of the potential market, was estimated at $1.5 billion in 2008. The report forecasts rapid growth driven by various factors including increased adoption in various clinical areas and international market trends.
About BioLife Solutions, Inc.:
BioLife Solutions develops and markets patented hypothermic storage/transport and cryopreservation media products for cells, tissues, and organs. The Company's proprietary HypoThermosol® and CryoStor™ platform of biopreservation media products are marketed to academic research institutions, hospitals, and commercial companies involved in cell therapy, tissue engineering, cord blood banking, drug discovery, and toxicology testing. BioLife's cGMP products are serum-free and protein-free, fully defined, and formulated to reduce preservation-induced, delayed-onset cell damage and death. BioLife's enabling technology provides research and clinical organizations significant improvement in post-preservation cell and tissue viability and function. For more information please visit www.biolifesolutions.com.
About IBET- Instituto de Biologia Experimental e Tecnologica:
Instituto de Biologia Experimental e Tecnologica (IBET) is a private not for profit institution created in 1989 to integrate and strengthen biological and biochemical knowledge from its academic and industrial partners into technology and transfer it into economic wealth and job creation. Science and technology are used together to ensure the translational application of competences from early stage discovery to final production and processes. IBET has 20 years of experience in biopharmaceuticals development and over 10 years experience in cell line creation and cryobiology. In its Animal Cell Technology Laboratory, work has been ongoing with recombinant and fusion proteins for diagnostics and therapeutics, subunit and virus like particle (VLP) vaccines, vectors for gene therapy (retro-, lenti-, adeno- and, more recently, baculovirus) and stem cells for cell therapies (neuronal, hepatocytes). For more information please visit http://www.ibet.pt/.
About Fraunhofer Institute for Biomedical Engineering:
The Fraunhofer Institute for Biomedical Engineering IBMT is your partner in offering solutions for individual tasks in the areas of Biomedical-/medical engineering, sensor- and measuring technologies, ultrasound technologies, health telematics, biotechnology and biohybrid technology, cryo(bio)technology and nano(bio)technology, environmental control systems, material testing, home systems, air quality control and security systems as well as industrial process automation and in-line/on-line process control.
For more information please visit http://www.ibmt.fraunhofer.de/fhg/ibmt/index.jsp.
This news release contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These forward-looking statements include any statements that relate to the intent, belief, plans or expectations of the Company or its management, or that are not a statement of historical fact. Any forward-looking statements in this news release are based on current expectations and beliefs and are subject to numerous risks and uncertainties that could cause actual results to differ materially. Some of the specific factors that could cause BioLife Solutions' actual results to differ materially are discussed in the Company's recent filings with the Securities and Exchange Commission. BioLife Solutions disclaims any obligation to update any forward-looking statements as a result of developments occurring after the date of this press release.
Media Relations: Investor Relations: Len Hall Matt Clawson Allen & Caron Inc Allen & Caron Inc (949) 474-4300 (949) 474-4300len@allencaron.com matt@allencaron.com
First Call Analyst:
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SOURCE: BioLife Solutions, Inc.
CONTACT: Media Relations, Len Hall,
Relations, Matt Clawson,
+1-949-474-4300, for BioLife Solutions, Inc.
Web Site: http://www.biolifesolutions.com/
We believe the promise of cell and gene therapies starts with the integrity of a single cell
Advancing the future of cell and gene therapy
The human body can heal itself. Cell and gene therapies are designed to augment the patient’s ability to fight disease but only if the living cells behind those therapies remain viable and functional throughout the production processes. At BioLife Solutions, our mission is to protect the integrity of cells and provide trusted tools, services, and expertise that can enable our customers to advance the development and delivery of cell and gene therapies. We believe the future of cell and gene therapies hinges on the integrity of every single cell and we are here to protect that promise.
We understand the technical demands of bioprocessing in this field, and our advanced biopreservation expertise, cell culture optimization products, innovative storage systems, and closed-system manufacturing solutions are designed to enhance process efficiency, maintain cellular viability, and ensure reproducibility at every stage. Whether scaling up from R&D, navigating clinical trials or optimizing cryopreservation protocols for commercial production, we provide the tools and experience to streamline your workflow and safeguard your therapies.
Streamline workflows and safeguard therapies
GMP-COMPATIBLE
Precision
biopreservation
for
maximum
viability
GMP-COMPATIBLE
Our biopreservation media and storage solutions are engineered to maintain cell integrity and functionality. With GMP-compatible, validated formulations, we help you reduce variability and improve post-thaw recovery, ensuring robust and reproducible outcomes.
CELL VIABILITY
Best
practices
in
cell
processing
CELL VIABILITY
With deep industry experience, regulatory support, and a commitment to innovation, BioLife Solutions is dedicated to supporting bioprocess engineers in overcoming complex manufacturing challenges. Whether optimizing cryopreservation protocols or ensuring the seamless transition from lab to clinic, we are dedicated to your success.
QUALITY & COMPLIANCE
Scalable
manufacturing
and
process
optimization
QUALITY & COMPLIANCE
Enhance efficiency and consistency in your cell processing workflow with our closed-system tools for fluid management and cell processing that are automation ready. Reduce manual handling errors, improve throughput, and achieve higher standards of quality and compliance as you scale towards commercialization.
REGULATORY SUPPORT
Your
partner
in
bioprocess
optimization
REGULATORY SUPPORT
BioLife Solutions delivers specialized tools and expertise to help bioprocess engineers streamline and strengthen biopreservation processes across the cell therapy workflow. From selecting the right biopreservation media to minimizing cell loss during freezing, storage, and transports, our solutions are designed to improve consistency, reduce risk, and support a successful transition from development to clinical application.
Work with experts who understand your biopreservation challenges
Connect with
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Collaborative and comprehensive CDMO support
At BioLife Solutions, we partner with leading contract development and manufacturing organizations (CDMOs) to enhance their biopreservation and cell processing capabilities. By providing advanced tools, regulatory support, and process optimization strategies, we empower CDMOs to better serve therapy developers, ensuring quality, consistency, and scalability in cell therapy manufacturing.
Regulatory
readiness
Navigating the complex regulatory landscape of cell and gene therapy requires a proactive approach. BioLife Solutions offers experienced regulatory support to help prepare your biopreservation and cell processing methods to meet global standards. From IND and BLA submissions to compliance with GMP, FDA, and EMA guidelines, our solutions help streamline approval pathways.
STORE
CellSeal®
CryoCase
Alleviate CGT container challenges like fracture risk, bag burping or high rates of particulates
Data-driven
decision making
Stay ahead with our comprehensive Evidence Library, a curated collection of scientific publications, white papers, and case studies demonstrating the efficacy of BioLife Solutions’ technologies. Access peer-reviewed research, real-world application data, and expert insights to support your bioprocessing and regulatory strategies.
